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While some people have speculated that the phase of the menstrual cycle could impact outcomes of primary surgical treatment in premenopausal women with breast cancer, the relationship between menstrual cycle phase during surgery and disease-free survival and overall survival has been unclear. The study involved women who reported a last menstrual period LMP within 42 days before surgery. The researchers used the date of the LMP to determine the phase of the menstrual cycle.
For nearly two decades, multiple retrospective reports, small prospective studies, and meta-analyses have arrived at conflicting results regarding the value of timing surgical intervention for breast cancer on the basis of menstrual cycle phase. Premenopausal women age 18 to 55 years, who were interviewed for menstrual history and who were surgically treated for stages I to II breast cancer, had serum drawn within 1 day of surgery for estradiol, progesterone, and luteinizing hormone levels. Menstrual history and hormone levels were used to determine menstrual phase: luteal, follicular, and other.
Biography: Syed Mozammel Hossain. In premenopausal women with metastatic hormone receptor-positive breast cancer, hormonal therapy is the first-line therapy. The pattern of recurrence risk over time after primary surgery suggests that peri-operative factors impact recurrence.
Please take this quick survey to tell us about what happens after you publish a paper. Breast Cancer Research and Treatment. Wearing a special thermometric brassiere, selected women self-measured their breast surface temperature.
Study record managers: refer to the Data Element Definitions if submitting registration or results information. Rationale: Previous research suggests that women who have their ovaries removed as part of their treatment for breast cancer may live longer if the ovarian surgery is performed during the luteal phase last 14 days of the menstrual cycle rather than the follicular phase the first 14 days of the menstrual cycle. The current study will evaluate this important research question in premenopausal women with metastatic hormone receptor-positive breast cancer who will be treated with surgery and tamoxifen.
Victorian government portal for older people, with information about government and community services and programs. Type a minimum of three characters then press UP or DOWN on the keyboard to navigate the autocompleted search results. The average length of the menstrual cycle is 28—29 days, but this can vary between women and from one cycle to the next.
There is some evidence that breast cancer surgery during the luteal phase in pre-menopausal women is associated with a better clinical outcome, however the evidence for this is still equivocal. In this paper, after summarizing the normal physiology of the menstrual cycle, we examine how such an association may occur and provide a comprehensive review of the literature in the area. Breast cancer is a significant disease affecting over 41, women each year in the UK [ 1 ].
A meta-analysis has been performed of available retrospective reports concerning the year disease-free survival of 5, premenopausal breast cancer patients operated on either during the follicular or luteal phases of the menstrual cycle. Improvement in prognosis was greatest for patients with the highest risk of recurrence due to node-invasive disease and receptor dysfunction. Several cell-mediated immunologic factors inimical to metastasis are maximal in the luteal phase of the menstrual cycle, including natural killer cell activity. A new drug which augments natural killer cell activity may extend any beneficial survival results to post-menopausal breast cancer patients in the future.